诺奖官网对2015年诺贝尔化学奖得主林达尔的采访

Interview with Tomas Lindahl

 

[Tomas Lindahl] Tomas here.

 

[Adam Smith] Oh, hello, my name’s Adam Smith, calling from Nobelprize.org, the official website of the Nobel Prize in Stockholm.

 

[Tomas Lindahl] Hello.

 

[Adam Smith] Hello. Many congratulations on the award of the Nobel Prize.

 

[Tomas Lindahl] Thanks very much. 

 

[Adam Smith] Could you tell me, how did you hear the news?

 

[Tomas Lindahl] I had a phone call early this morning, just a couple of hours ago, I guess, or an hour ago, from the Swedish Academy, telling me this very good news.

 

[Adam Smith] An amazing phone call to get. What was your first reaction?

 

[Tomas Lindahl] Well, surprise, to some extent, not 100% surprise, because I’m getting up in the years and I know that I have been one of the well known scientists in my field of science, which is DNA repair for many years. So the question was: will there be a Prize for DNA repair? And I think many people have now realised it’s a very important topic of research, and if so, there would be 10, 15 excellent people you could choose from, and you can’t give the Nobel Prize to more than three people. So I feel very lucky and privileged to be included in the top class that was awarded.

 

[Adam Smith] And it must be very special because I think you’re the first Swede to receive the Chemistry Prize for 67 years, since Tiselius...

 

[Tomas Lindahl] That may well be, yes.

 

[Adam Smith] Does that make it more special?

 

[Tomas Lindahl] Yes, I think so, because I got my initial training in Sweden, and I also had the difficult decision to do there, in that I was studying medicine, and research started looking very interesting and intriguing, so should I put aside my clinical studies for some time and concentrate on the research instead. And that’s a risky decision to make for a young fellow, but I took the chance and I think it has worked out. 

 

[Adam Smith] It has paid off, yes. As you say, the Prize is for the field of DNA repair and you’re considered a sort of a father figure in the field, and you’ve devoted your life also to cancer research for some decades, and...

 

[Phone beeps]

 

[Tomas Lindahl] Pardon.

 

[Phone beeps]

 

[Tomas Lindahl] I’m not a politician, I’m not used to talking on two phones at the same time. Sorry.

 

[Adam Smith] I was just saying you’ve devoted your career to cancer research for some decades also, and these DNA repair mechanisms, they help protect our DNA, but they also, in some ways, help protect cancer cells, don’t they?

 

[Tomas Lindahl] Yes, that’s an important topic of modern research. We want to understand repair mechanisms in some detail so that we can prevent the cancer cells from repairing DNA when we, for example, expose them to radiotherapy. But we do need the repairs to protect us against DNA damage that occurs inevitably.

 

[Adam Smith] And lastly, would you say the prospects for cancer research, for treating cancer or at least for turning cancer into a chronic disease, are good at the moment?

 

[Tomas Lindahl] Yes, that is a very good and hot topic, not only for cancer but I think for many diseases. In this case, we are getting away a little bit of trying to find a cure for everything and convert diseases into something we can live with. The reason we’ve had for a long time with diabetes. It’s difficult to cure diabetes, but we have good ways of treating diabetic patients. And I think with regard to DNA damage, that will be increasingly important aspect of it. I’m home now because I was going to do some writing at home today, but after this message, it was decided that a driver will take me out to the laboratory where the work has been done in North London.

 

[Adam Smith] Yes.

 

[Tomas Lindahl] That’s the Clare Hall Laboratories.

 

[Adam Smith] Are you enjoying this? This attention?

 

[Tomas Lindahl] Of course. It’s always nice at the end of your career to have recognition that what you have done is actually important.

 

[Adam Smith] Indeed, indeed. Well, how lovely to speak to you, thank you. I look forward to seeing you again in Stockholm in December and hopefully sooner in London.

 

[Tomas Lindahl] OK.

 

[Adam Smith] Thank you. Bye bye. Congratulations.